Jyh-Lyh (Jerry) Juang Lab
Welcome to the Juang Lab. Led by Dr. Jyh-Lyh (Jerry) Juang, our team is dedicated to uncovering the systemic and molecular drivers of Alzheimer’s Disease (AD). We are an interdisciplinary research group focusing on the intersection of Neuroscience, Immunology, and Microbiology to solve the complexities of AD.
About Us
The Juang Lab operates at the forefront of translational neuroscience. We believe that AD is not just a localized brain disorder but a systemic condition influenced by inter-organ communication and genetic predispositions. Our mission is to decode the "dialogue" between the brain and the rest of the body, specifically the gut microbiome and the immune system, to develop precision therapies for AD.
Selected Publications
Our work is frequently featured in high-impact journals, reflecting our commitment to rigorous and influential science:
- Lai R, et al. (2026). Why 11β-HSD1 inhibitors show variable efficacy in Alzheimer's therapy: an APOE4-dependent HSD11B1 mechanism. Theranostics.
- Lai RH, et al. (2025). Sex- and APOE Genotype-Dependent Pain Susceptibility and Alzheimer's Risk Mediated by the Lipid Metabolism Enzyme LPCAT2. Aging Cell (Cover Story).
- Lai RH, et al. (2022). Vitamin D supplementation worsens Alzheimer’s progression: animal model and human cohort studies. Aging Cell.
- Wu TH, et al. (2020). A supramolecular bait to trigger non-equilibrium co-assembly and clearance of Aβ42. Angewandte Chemie.
- Wu SC, et al. (2017). Intestinal microbial dysbiosis aggravates the progression of Alzheimer’s disease in Drosophila. Nature Communications.
- Wu SC, et al. (2012). Infection-induced intestinal oxidative stress triggers organ-to-organ immunological communication. Cell Host & Microbe.
Join Our Team
We are looking for passionate, curious, and driven students (Masters and Ph.D. candidates) who want to challenge the status quo of Alzheimer’s research. In the Juang Lab, you will gain expertise in functional genomics, advanced imaging, microbiome analysis, and animal models of disease.
Contact Information
PI: Jyh-Lyh (Jerry) Juang, Ph.D.
e-mail: juang@mail.cmu.edu.tw
phone: 04-2205-3366 #7953
Please contact the laboratory office for application inquiries and visiting opportunities.
